Denali Therapeutics Inc. (DNLI) /

The profitability of Denali Therapeutics Inc. over the past 10 years

Chart Denali Therapeutics Inc.: operating income, net income, fiscal 2016–2025 Open the chart →

Denali Therapeutics Inc. reported a net loss of $512.54M in fiscal 2025, the latest fiscal year on file. That year it had an operating loss of $555.34M. It reported a profit in 1 of the 10 years shown, and a loss in fiscal 2016, 2017, 2018, 2019, 2021, 2022, 2023, 2024 and 2025. Its highest net income in these years was $71.14M, in fiscal 2020.

Year by year

Fiscal yearOperating incomeNet income
2025ended Dec 31, 2025-$555.34M-$512.54M
2024ended Dec 31, 2024-$487.34M-$422.77M
2023ended Dec 31, 2023-$196.7M-$145.22M
2022ended Dec 31, 2022-$340.74M-$325.99M
2021ended Dec 31, 2021-$295.75M-$290.58M
2020ended Dec 31, 2020$62.72M$71.14M
2019ended Dec 31, 2019-$213.18M-$197.61M
2018ended Dec 31, 2018-$46.37M-$36.24M
2017ended Dec 31, 2017-$90.14M-$88.19M
2016ended Dec 31, 2016-$87.43M-$86.65M

Fiscal years as Denali Therapeutics Inc. reports them. * Calculated by us from the company's filed figures; — no figure on file. From SEC filings, updated nightly. How each line is read.

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Not investment advice. This page shows what Denali Therapeutics Inc. filed with the SEC. Nothing here is a recommendation about any security. Check important figures against the company's own filings.